The future progression of -deficiency constitution research should incorporate the development of objective constitution identification methods, the establishment of appropriate animal models, the pursuit of high-evidence research into the constitution and associated diseases, and an in-depth examination of the full range of nine constitutions. This comprehensive approach will yield more objective and scientific results.
A study into acupuncture prescription efficacy for functional gastrointestinal disorders (FGIDs), exploring the special, co-effect, or synergistic outcomes, considering the characteristics of single or compatible acupoints and the variations in acupuncture techniques, will be undertaken.
Employing the established search strategy, we delved into six electronic bibliographic databases, generating a summary for this overview.
Extensive research demonstrates acupuncture's beneficial impact on Functional Gastrointestinal Disorders (FGIDs). However, the prescription intervention employed a selection of unique single acupoints, compatible acupoints, and acupoints chosen through expert consensus.
The core acupoints, including Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), rely on the application of particular acupoints, meridian points, and nerve segments, and the two-way regulatory mechanism observed in this study guides the selection and formulation of acupoint treatments for FGIDs.
The acupoints Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), crucial in the treatment of functional gastrointestinal disorders (FGIDs), highlight the application of targeted acupoints, related meridians, and nerve components, while the study's findings of bi-directional regulation guide the selection and creation of effective acupuncture protocols.
By integrating meta-analytic and bioinformatics strategies, a preliminary exploration of the potential mechanism of Yinyanghuo and its extract in chronic obstructive pulmonary disease (COPD) will be conducted.
A meta-analysis was initially performed. Yinyanghuo's use in treating COPD was examined in Chinese and English literature through a systematic search technique that combined subject-specific keywords with general keywords. Following evaluation by the SYRCLE risk bias assessment tool, the review manager software was employed to aggregate effect quantities for subsequent statistical analysis of the included studies. Applying bioinformatics technology, an evaluation of the active ingredients and their targets of Yinyanghuo was performed, which, through mapping and comparison with COPD targets, yielded intersecting genes. A model, which integrates medicinal materials, compounds, and targets, was created, and the key pathways were marked. At last, the primary focus was attached to its requisite compounds.
Eight studies were part of this meta-analysis's dataset. The COPD model treated with Yinyanghuo (Herba Epimedii Brevicornus) displayed a considerable reduction in pro-inflammatory factors, exemplified by tumor necrosis factor- (TNF-) and interleukin (IL)-8, alongside a marked increase in anti-inflammatory factors and antioxidant factors, such as IL-10 and phospho-protein kinase B (p-AKT). Statistically significant changes were observed in all cases (all P < 0.05). A study using bioinformatics methods uncovered 23 active components and 102 target genes from Yinyanghuo (Herba Epimedii Brevicornus). Of these, 17 compounds and 63 targets showed a strong correlation with COPD. virologic suppression Key pathways revealed by enrichment analysis were the TNF signaling pathway, the PI3K/Akt signaling pathway, the cancer signaling pathway, and the accompanying inflammatory reactions, oxidative stress, and tumor-related pathways. The molecular docking experiments on 24-epicampesterol's top 5 components interacting with 10 core targets, such as IL-6, produced binding energy fractions all less than 50 kcal/mol, suggesting promising binding potential.
According to bioinformatics and meta-analysis, the therapeutic effect of Yinyanghuo, including its constituent parts, against COPD may stem from its ability to neutralize inflammation and oxidative stress. Early findings suggest Yinyanghuo holds potential as a natural remedy for the prevention and treatment of COPD.
Meta-analysis and bioinformatics research suggest that Yinyanghuo's and its constituents' therapeutic benefit in COPD might stem from their ability to counteract inflammation and oxidative stress. HIV – human immunodeficiency virus The observed outcomes are an initial step towards understanding Yinyanghuo's potential efficacy as a natural COPD prophylactic and therapeutic agent.
In China, approximately half of knee osteoarthritis (KOA) cases are treated using Traditional Chinese Medicine or a combination of Traditional Chinese and Western medicine, making objective efficacy evaluations crucial. In the design of prospective clinical tests, multi-source data collection, processing, and fusion were the main approaches, represented by 150 KOA patients and 100 healthy individuals. With the help of a tongue inspection application, an infrared instrument, and a channel instrument, among others, data were gathered. Modeling, analysis, screening, and fusion were applied to the multi-source data. This study integrated traditional clinical tests with a tailored information platform, improving efficiency in clinical testing, medical follow-up procedures, and timely feedback for statistical data analysis.
The quality of life (QOL) of patients with malignant tumors may be adversely affected by the suppression of cellular immune function, a potential side effect of radical mastectomy. Adverse reactions and complications in the adjuvant therapy regimen, following radical mastectomy for breast cancer, are frequently related to immune suppression. Treatment options for immune system suppression are presently few and demonstrably effective. Hence, the creation of a fresh treatment strategy is crucial. Widespread clinical use is seen for the press needle. Still, the exploration of press needle's influence on postoperative immune function has been undertaken in a relatively limited number of research endeavors. This study intends to measure the impact that press needles have on the immune system and quality of life of female breast cancer patients after undergoing radical mastectomy. This single-center study will utilize a randomized and single-blinded approach. 78 eligible patients, divided in an 11:1 ratio, will be randomly assigned either to the press needle group or the sham press needle group. During the two-week treatment period, patients will undergo verum press needle or sham press needle therapy five times weekly. The primary outcome measures are the levels of CD8+, CD4+, CD3+, and CD4+/CD8+ T cells in the peripheral blood. Secondary outcome assessment will entail evaluating alterations in patient quality of life, employing both the Karnofsky Performance Scale and the EORTC QLQ-C30 quality of life questionnaire. Furthermore, an evaluation of the 5-year survival rate and the recurrence rate will be conducted. Each visit will involve an assessment of safety and adverse events. An ongoing clinical trial comparing press needle therapy with a sham procedure will generate evidence regarding its effects on immune function and quality of life for breast cancer resection patients. The Chinese Clinical Trial Registry, ChiCTR2000040100, serves as the trial's registration. The registration entry specifies November 21, 2020, as the registration date.
The microbial community structure of various tongue coating types was examined in patients with chronic gastritis to explore the correlation between the tongue's microbiome and oral health.
A study employing 16S rDNA gene sequencing and bioinformatics unveiled the dynamic changes and correlations of microbial flora in three groups: patients with chronic gastritis, healthy controls, and those with different tongue fur appearances. Additionally, the conversation encompassed the connection between the degree of gastritis and the microorganisms found within the tongue's coating.
A substantial disparity in tongue fur microbial diversity was found between individuals with chronic gastritis and healthy individuals. The diversity and relative abundance of bacterial communities exhibited significant alterations in patients with extra tongue fur, unlike those seen in healthy individuals. The predominant bacteria found within the tongue fur microbiota were oral bacteria, displaying relative abundances between 1% and 0.05%, encompassing a multitude of 12 phyla, such as and , and 256 genera, including and .
Changes in the oral flora of patients suffering from chronic gastritis were demonstrably connected to the presence of tongue fur. Consequently, the considerable microbiota inhabiting the mouth could stimulate further investigation of the link between tongue inspection and oral microbiota in individuals with chronic gastritis.
The presence of tongue fur correlated with alterations in oral bacterial populations in individuals with persistent gastritis. read more In consequence, the substantial microbial community warrants further investigation into the connection between tongue observation and oral microbiota in patients with chronic gastritis.
Analyzing the clinical outcomes of acupuncture therapy, along with fascia, meridian, and nerve stimulation, alongside ultrasound-guided nerve blockage, in the treatment of patients with postherpetic neuralgia.
During the period from May 2019 to June 2021, the Pain Department of Xiyuan Hospital, affiliated with the China Academy of Chinese Medical Sciences, recruited a cohort of 61 outpatients diagnosed with post-herpetic neuralgia affecting the chest and back. Randomly, they were assigned to either of the two groups. Of the 31 patients in the control group, 30 received only ultrasound-guided thoracic paravertebral nerve blocks (PVBs). One patient withdrew. In the observation group, 30 patients received acupuncture along the fascia, meridians, and nerves, along with ultrasound-guided PVB treatment. Treatments were administered weekly to both the control and observation groups, spanning four weeks.